Endocrine Abstracts

Background: Polycystic ovary syndrome is the most common endocrine disorder among women in their reproductive years. Apart from reproductive and metabolic manifestations, recently more attention has been paid to psychological features of this syndrome. The aim of the study was to evaluate the effect of PCOS on quality of life and to estimate the frequency of anxiety and depression in Polish women with PCOS.Methods: One hundred seventy five women with PCO...

Introduction: Polycystic ovary syndrome (PCOS) is one of the most commonly diagnosed endocrinopathies in women of reproductive age and is associated with an increasing number of metabolic comorbidities. About 50% of PCOS patients are obese, while insulin resistance affect up to 70% of these women. The endocannabinoid system contributes to human energy homeostasis. CNR1 is a biological candidate for human obesity and related metabolic disorders.Aims: The ...

Polycystic ovary syndrome (PCOS) is an endocrine disorder with a pathogenesis in which hormonal and metabolic disturbances have been considered. There is evidence of a familial aggregation of hormonal and metabolic abnormalities in siblings of PCOS women. Some of the female relatives fulfill the diagnostic criteria of PCOS. Premature balding in the age of <30 has been proposed as the male phenotype in PCOS families.The aim of the study was to determi...

Polycystic ovary syndrome (PCOS) is an endocrine disorder in women of reproductive age. Hormonal disturbances, metabolic disorders, and more recently, chronic inflammation have been considered in pathogenesis of PCOS. One of the determinants of inflammation investigated in terms of insulin resistance (IR) is paraoxonase 1 (PON1).Aim: To evaluate PCOS patients for the existence of chronic inflammation and to assess the relationship among PON1 polymorphism...

Results of many studies indicate that the BsmI polymorphism in the vitamin D receptor (VDR) gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of osteoporosis. As far as long-term glucocorticoid treatment is a major risk factor for osteoporosis development, we looked for the BsmI VDR gene polymorphism and its relation to phenotypic features characterizing bone status (BMD and metabolic bone turnover) in 74 premenopausal women: 5...

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age characterized by chronic anovulation and hyperandrogenism, and also associated with insulin resistance. Subclinical chronic inflammation might be an important pathogenetic factor in the development of insulin resistance, type 2 diabetes and recently has been also observed in PCOS. There is evidence for a familial predisposition not only to hormonal abnormalities but also to metabolic d...

Polycystic ovary syndrome (PCOS) is a common endocrine abnormality connected not only with reproductive problems but also with impaired energy homeostasis leading to metabolic disorders including metabolic syndrome. Irisin (Ir), recently identified novel myokine, has been proposed to mediate some of the positive influence on metabolic disorders. The aim of our study was to search the relationship between Ir plasma concentration in PCOS in the context of metabolic disturbances....

Introduction: Results of many studies indicate that BsmI polymorphism in VDR gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of glucocorticoid-induced osteoporosis.Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI) and its relationship to phenotypic features characterizing bone status (BMD and metabolic bone turnover).Material and methods: Followin...

Objective: To measure the levels of 25-hydroxyvitamin D (25(OH)D) and vitamin D binding protein (VDBP) and assess their relationships with metabolic features in patients with the polycystic ovary syndrome (PCOS).Methods: 267 women, aged 20–35 years (24.7±4.9): 167 with PCOS, 100 healthy women as a control group were studied. Study groups were divided according to body mass index (BMI). Biochemical and hormonal parameters, 25(OH)D, VDBP were mea...

In the 1980s the concept, that some individuals with normal weight (Metabolically Obese, Normal-Weight) have disturbances of metabolism, related to obesity was proposed. It is known, that obesity promotes atheromatosis by various mechanism, inter alia due to excess of inflammatory markers. This problem however, was not investigated in non-obese subjects.We analyzed anthropometric variables, body fat distribution by DXA and serum CRP, Il-6 and Il-18 in 43...